Computational modification of the Acyclic Maleimide-based enediyne for pH dependent drug release

Abra Granger

This research focuses on exploring the energetics and pH selectivity of a maleimide-based acyclic enediyne as a potential avenue for anti-tumor treatment. In this study, I look at the energetics of various enediyne molecules to extract useful information about how changes in pH dependent groups affect the overall energy of reaction and energy barriers of these molecules.




Carol Parish