Characterization of Hypothetical Proteins in Proteus Mirabilis

Emily Ward, Juliette Copeland

Proteus mirabilis is a gram-negative pathogenic bacteria often found in the urinary tract of humans. It is predicted to cause 1-10% of all urinary tract infections (UTIs), particularly patients undergoing catherization. It can produce urease which generates ammonia and subsequently increases the pH levels of urine. As antibiotic resistance of P. mirabilis continues to rise, more research must be conducted in order to better understand the bacterium's function. This study aims to increase the known data about P. mirabilis through the examination of hypothetical proteins within the bacterium's genome. Hypothetical proteins are sequences of putative biomolecules that have been identified computationally following genome sequencing and little to no information is known regarding their function. This study examines the structure and function of 100 proteins within the P. mirabilis genome with the use of online bioinformatic tools. This work will help to increase our knowledge of the proteome of P. mirabilis and may help to eventually formulate new treatment options

Department:

Biochemistry and Molecular Biology

Mentor(s):

Jonathan Dattelbaum